Get to Know You for Teens

A teen gets a dose of Pfizer's COVID-19 vaccine concluding month at Holtz Children's Infirmary in Miami. Nearly seven million U.Due south. teens and preteens (ages 12 through 17) accept received at least ane dose of a COVID-nineteen vaccine and then far, the CDC says. Eva Marie Uzcategui/Bloomberg via Getty Images hide caption

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Eva Marie Uzcategui/Bloomberg via Getty Images

It's been a picayune more than a month since adolescents equally young equally 12 became eligible in the Us to receive the Pfizer vaccine confronting COVID-nineteen, and nearly all reports have been positive: The vaccine is very effective in this age group, and the vast majority of kids feel balmy side effects, if any — the aforementioned sore arm or mild flulike symptoms seen amid adults who get the shot.

The Centers for Disease Control and Prevention has recommended that anybody 12 and older go vaccinated against COVID-xix, and the rollout is well underway: According to the CDC last calendar week, around 7 one thousand thousand U.Southward. teens and preteens (ages 12 through 17) had received at to the lowest degree one dose of a COVID-19 vaccine so far.

Nevertheless, before long subsequently the Food and Drug Assistants authorized the use of Pfizer'south vaccine in young people, federal agencies began receiving reports of mild chest pain or other signs of possible heart inflammation (known as myocarditis) in a small per centum of teens and young adults before long after vaccination.

According to the CDC, subsequently a meeting of expert advisors discussed the data Midweek, more than than 300 cases of heart inflammation have been documented subsequently the Pfizer or Moderna COVID-nineteen vaccines. The cases have been seen by and large in teens and young adults between 12 and 39 years onetime, the agency says. Symptoms tin can include chest hurting or pressure and a temporarily aberrant ECG and blood test results.

Naturally occurring heart inflammation is rare, merely information technology does occur from time to time in teens and young adults. The rate seen after these vaccines is slightly college than the "groundwork" charge per unit.

The CDC says the findings do non change the basic recommendation that all people 12 and older should exist vaccinated against COVID-19. However, if a person develops myocarditis later the first dose of 1 of the mRNA vaccines, a second dose should exist delayed until the condition has fully resolved and the middle has returned to a normal state.

So, should parents of teens hesitate to have their kids vaccinated confronting COVID-xix?

Vaccine experts and the American Academy of Pediatrics say no, don't hesitate. Information technology'due south good for doctors and patients to be aware that there might exist a connection between the mRNA vaccines and heart inflammation, and to written report to their pediatrician anything they run across in that offset week after vaccination. But it is likewise important, the CDC notes, to recognize that fifty-fifty if this does plow out to exist an extremely rare side upshot of the vaccine, "almost patients who received care responded well to medicine and rest and quickly felt meliorate." And the serious risks of COVID-19 — even for young healthy people — outweigh the risks of any possible side effects from the vaccine. Here are some questions you may have, and what's known:

What exactly is myocarditis?

Myocarditis is an inflammation of the centre muscle, and pericarditis, besides being investigated, is an inflammation of the sac around the heart.

Long before the pandemic, thousands of cases of myocarditis were diagnosed in the U.South. and around the globe each twelvemonth, often triggered by the body's immune response to infections. SARS-CoV-2, the virus that causes COVID-19, can trigger information technology, and so tin can cold viruses, and staph and strep and HIV. Other causes include toxins and allergies.

Symptoms include chest pain and shortness of jiff. Information technology's often mild enough to get unnoticed, just a full-blown case in adults can cause arrhythmias and centre failure that require conscientious treatment with multiple medications, and several months of strict remainder. In a instance report of seven teenagers who got myocarditis following vaccination published last week in the journal Pediatrics, all vii got improve after routine handling with anti-inflammatory drugs.

Pediatric cardiologist Stuart Berger of the Northwestern University Feinberg School of Medicine, a spokesperson for the American University of Pediatrics, says vaccine-related myocarditis in teens is not all that worrisome. "Although they appear with some symptoms of chest hurting, and maybe some findings on EKGs, all of the cases nosotros've seen accept been on the balmy end of the spectrum," he says.

So, what'due south the business?

Several hundred reports almost the inflammation take been filed with the federal regime's Vaccine Adverse Event Reporting Organization, or VAERS; that'due south a repository of reports sent in by wellness professionals and patients near any health events they spot in the hours or days after vaccinations. Many of the events reported turn out to be casual — non caused past a vaccine. The database is just meant every bit a starting bespeak for farther investigation and not proof of crusade and outcome. Only as NPR's Geoff Brumfiel has reported, "when millions of people are vaccinated within a short catamenia, the total number of these reported events can await big."

That said, anecdotes reported by doctors in medical journals and reports to VAERS suggest that both of the mRNA vaccines authorized for utilise in the U.S. — the Pfizer and Moderna vaccines — might slightly increment the incidence of myocarditis in young people. In 2003, a report in The New England Journal of Medicine estimated the background incidence of myocarditis to be i.13 cases in 100,000 children per twelvemonth.

Paul Offit, professor of pediatrics at the Children's Hospital of Philadelphia and a fellow member of an FDA vaccine advisory committee, says there likely is a causal link between the heart inflammation some doctors are seeing in these teens and the 2d dose of vaccine. "I think information technology's real," he says, only he hastens to add together that the upshot is exceedingly small — based on the data collected so far, maybe 1 in l,000 vaccinees betwixt the ages of sixteen and 39. "And the good news is at least so far it looks to be transient and cocky-resolving."

Co-ordinate to the CDC, at that place have been some cases of heart inflammation reported to the Vaccine Adverse Events Reporting Organization after the Johnson & Johnson vaccine, though not as many as have been seen after the Moderna and Pfizer vaccines.

The federal wellness agency confirmed Wednesday that most people who take experienced this side effect have recovered from symptoms and are doing well. Nine remained in the infirmary as of last week and more than than 300 others accept been discharged. No deaths have been associated with this side issue.

Nevertheless, possibly I should wait to go my teen vaccinated and see how this plays out?

Uhm, no, according to several vaccine experts contacted by NPR. And this is where a trivial math comes in handy.

"Take a stadium full of 100,000 people between the ages of 16 and 39, which is the subset that appears to be at greater gamble," Offit says. "Vaccinate all of them, and two might become myocarditis." But if you don't vaccinate whatsoever of the 100,000, he estimates that well-nigh i,300 would somewhen become COVID-19. And those numbers are likely to increase this wintertime.

About ane in 1,000 children who go COVID-19 have gone on to develop a condition called MIS-C (multisystem inflammatory syndrome in children), says Offit, and nearly of those kids accept had some level of myocarditis. In add-on, the coronavirus has directly acquired myocarditis in some children and adults. Which of the two stadiums in Offit's metaphor would have more cases of myocarditis — the vaccinated children or unvaccinated kids — is not known precisely. Only Offit says he suspects it would be the unvaccinated grouping. And there's no uncertainty that 1,000 unvaccinated children would suffer more illnesses related to COVID-19. "A choice not to get a vaccine is not a choice to avoid myocarditis," he says. "It's a choice to take a different take chances — and I would argue a more serious one" — of developing a bad case of COVID-xix or long COVID-nineteen or myocarditis as a result of COVID-19.

Are the experts advising their own kids in this age group to become vaccinated?

Yep. "I understand people having concerns," Dr. Judith Guzman-Cottrill says. She'southward a parent and professor of pediatric infectious diseases at the Oregon Health and Scientific discipline University as well as the senior author on a small written report that came out this calendar month in the journal Pediatrics. In the study, Guzman-Cottrill and her colleagues analyzed the cases of seven boys around the country who developed myocarditis within four days of receiving the Pfizer-BioNTech vaccine.

She and her family recently faced the vaccination conclusion for her 13-year-old daughter — and said a wholehearted yes to the shot.

Guzman-Cottrill suspects there may turn out to be a slightly increased take a chance of heart inflammation from vaccination in young people, but she and her co-authors annotation in the Pediatrics report that a straight cause-and-consequence connectedness — even in these vii cases they studied — has notwithstanding to be established. And she's impressed that despite the millions of doses that have and so far been delivered to teens, no articulate and serious post-vaccination problems take shown up. "The emergency departments and urgent intendance clinics are non filled with teenagers complaining of chest pain," she says.

She's treated unvaccinated teens who adult severe myocarditis from an infection with the COVID-19 virus, and others who developed COVID-19 pneumonia and respiratory failure. Seeing those teens struggle — lacking the powerful immune protection the vaccine provides — was enough for her to suggest vaccination to her daughter, who got her second vaccination this calendar week.

"She saw it as a pathway back to a normal, post-pandemic life," Guzman-Cottrill says.

And that's where public health comes in. "We really need a highly vaccinated student body when kids return to the classroom this fall," Guzman-Cottrill says, "then nosotros don't come across surges in COVID-nineteen cases."

Joanne Silberner, a sometime health policy correspondent for NPR, is a freelance journalist in Seattle.

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Source: https://www.npr.org/sections/health-shots/2021/06/17/1007447098/pfizer-covid-vaccine-teens-symptoms-myocarditis

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